Description
Pegaspargase (Oncaspar®) is an asparagine specific enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia.
Asparaginase Erwinia Chrysanthemi (Rylaze™) is an asparagine specific enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of individuals who have developed hypersensitivity to E. coli-derived asparaginase.
Calaspargase pegol-mknl (AsparlasTM) is an asparagine specific enzyme that catalyzes the conversion of the amino acid L-asparagine into aspartic acid and ammonia. The pharmacological effect is thought to be based on selective killing of leukemic cells due to depletion of plasma L-asparagine. Leukemic cells with low expression of asparagine synthetase have a reduced ability to synthesize L-asparagine, and therefore depend on an exogenous source of L-asparagine for survival.
