Saliva Hormone Testing

Effective Date: August 01, 2004
Revised Date: February 07, 2012
Last Reviewed: November 21, 2017

Description

Saliva hormone testing uses a saliva sample to measure levels of estradiol, progesterone, testosterone, cortisol, DHEA, melatonin or other hormones. Many proponents use this test to identify female hormone levels in perimenopausal women to initiate hormone replacement therapy.

Policy/Criteria

Benefits are not available for salivary hormone tests as it is considered investigational.

Billing and Coding

HCPCS S3650 Saliva test, hormone level; during menopause
S3652 Saliva test, hormone level; to assess preterm labor risk

Non-covered procedures

HCPCS S3650 Saliva test, hormone level; during menopause
S3652 Saliva test, hormone level; to assess preterm labor risk

Source

Plan Survey

American Association of Clinical Endocrinologists. Medical Guidelines for Clinical Practice for Management of Menopause. Endocrine Practice 1999; 5:355-366.

American College of Obstetricians and Gynecologists (ACOG) press release. SalEst™ not recommended as a screening tool for predicting premature labor. Washington, DC; January 31, 2001. Available online at http://www.acog.org/from_home/publications/press_releases/nr02-01-01-2.htm.

American College of Obstetricians and Gynecologists (ACOG). Compounded bioidentical hormones. ACOG Committee Opinion No. 322. Obstet Gynecol 2005; 106:1139-40.