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Biomarkers in Risk Assessment and Management of Cardiovascular Disease

Section: Laboratory
Effective Date: July 01, 2018
Revised Date: November 14, 2019


Numerous lipid and nonlipid biomarkers have been proposed as potential risk markers for cardiovascular disease. This policy will focus on those lipid markers that have the most evidence in support of their use in clinical care. The biomarkers assessed here are apolipoprotein B (apo B), apolipoprotein AI (apo AI), apolipoprotein E (apo E), B-type natriuretic peptide, cystatin C, fibrinogen, high-density lipoprotein (HDL) subclass, leptin, low-density lipoprotein (LDL) subclass, and lipoprotein A.


Coverage is subject to the specific terms of the member’s benefit plan.

Measurement of novel lipid and non-lipid risk factors (i.e., apolipoprotein B, apolipoprotein A-I, apolipoprotein E, B-type natriuretic peptide, cystatin C, leptin, LDL subclass, HDL subclass, lipoprotein[a]) are considered experimental/investigational and, therefore, non-covered, as an adjunct to LDL cholesterol in the risk assessment and management of cardiovascular disease. The available scientific evidence does not provide adequate data to establish that the use of panels that include lipid and non-lipid cardiovascular risk markers improve outcomes when used in clinical care.

Procedure Codes













The measurement of plasma brain natriuretic peptide (BNP) or NT-proBNP may be medically necessary for ANY ONE of the following indications:

  • Differentiating heart failure from pulmonary disease in a dyspneic individual; or
  • Monitoring response to treatment for heart failure; or
  • Risk stratification in a suspected acute coronary syndrome (ACS).

The measurement of plasma brain natriuretic peptide (BNP) or NT-proBNP testing for any other indication is considered experimental/investigational and, therefore, non-covered. Scientific evidence of safety and efficacy has not been proven.

Procedure Codes


Diagnosis Codes

Covered Diagnosis Codes for procedure code 83880

I20.0 I21.01 I21.02 I21.09 I21.11 I21.19 I21.21
I21.29 I21.3 I21.4 I21.A1 I21.A9 I22.0 I22.1
I22.2 I22.8 I22.9 I25.110 I25.700 I25.710 I25.720
I25.730 I25.750 I25.760 I25.790 I27.0 I27.20 I27.21
I27.22 I27.23 I27.24 I27.29 I27.83 I31.1 I42.0
I42.1 I42.2 I42.3 I42.5 I42.6 I42.7 I42.8
I42.9 I43 I50.1 I50.20 I50.21 I50.22 I50.23
I50.30 I50.31 I50.32 I50.33 I50.40 I50.41 I50.42
I50.43 I50.810 I50.812 I50.813 I50.814 I50.82 I50.83
I50.84 I50.9 I80.89 J90 J91.8 J94.1 J94.8
J94.9 J96.00 J96.01 J96.02 J96.20 J96.21 J96.22
J96.90 J96.91 J96.92 R06.00 R06.01 R06.02 R06.03
R06.09 R06.2 R06.3 R06.82 R06.83 R06.89 R06.9
R07.1 R07.2 R07.81 R07.82 R07.89 R07.9 R60.0

Non-covered Diagnosis Codes for procedure codes 82172, 83695, 83698, 83700, 83701, 83704, 83719,and 83722:

Z13.220 Z13.6 Z82.49