Confocal Laser Endomicroscopy

Section: Diagnostic Medical
Effective Date: March 01, 2020
Revised Date: January 22, 2020
Last Reviewed: January 22, 2020


Confocal laser endomicroscopy (CLE), also known as confocal fluorescent endomicroscopy and optical endomicroscopy, allows in vivo microscopic imaging of cells during endoscopy. CLE is proposed for a variety of purposes, especially as a real-time alternative to biopsy/polypectomy and histopathologic analysis during colonoscopy and for targeting areas to undergo biopsy in patients with inflammatory bowel disease or Barrett esophagus.


CLE is considered experimental/investigational and therefore, non-covered. The safety and/or effectiveness of this service cannot be established by review of the available published peer-reviewed literature.

Procedure Codes

0397T 43206 43252 88375