Professional Statements and Societal Positions Guidelines
American Society of Blood and Marrow Transplantation-2012
Evidence-based recommendations from the American Society of Blood and Marrow Transplantation (2012) advised that extracorporeal photopheresis (ECP)cannot be considered superior to horse antithymocyte globulin for the treatment of acute GVHD. This conclusion was based on older studies.
National Cancer Institute Acute and Chronic GVHD-2021
In its guidelines on childhood hematopoietic cell transplantation, the National Cancer Institute listed ECP as a second-line treatment for individuals with acute GVHD resistant to first-line methylprednisolone. For chronic GVHD therapy, the guidelines recommended that steroids are first-line therapy, but steroid-sparing approaches, including ECP, are being developed. In this setting, ECP has shown “some efficacy in a percentage of individuals.”
National Comprehensive Cancer Network-2021
National Comprehensive Cancer Network guidelines on primary cutaneous B-cell lymphomas (v.1.2021) lists the use of ECP as a category A treatment alone or in combination with other agents as first-line systemic therapy for advanced (stages III-IV) disease, as well as for individuals with either earlier stage mycosis fungoides with Sézary syndrome involvement.