The primary amyloidosis comprise a group of diseases with an underlying clonal plasma cell dyscrasia. These diseasesare classified bythe type of amyloidogenic protein involved and by the distribution of amyloid deposits. In systemic amyloidosis, the unnatural proteinis producedat a site that is remote from the site(s) of deposition,whereas, inlocalized disease, the amyloid light chain proteinis producedat the site of deposition.
Primary or amyloid lightchainamyloidosis (AL), the most common type of systemic amyloidosis, can cause organ dysfunction, most frequently in the kidneys, heart, and liver, although the central nervous system and brain may be affected.
HCT involves the intravenous (IV) infusion of allogeneic (donor) or autologous stem cells to reestablish hematopoietic function in individuals whose bone marrow or immune system is damaged or defective. They can be harvested from bone marrow, peripheral blood, or umbilical cord blood and placenta shortly after delivery of neonates.