Early intraperitoneal chemotherapy (EIPC) is administered directly into the abdominal cavity. The first dose of chemolytic agents may be infused post-surgery with subsequent doses given over a course of several days.
Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC), also referred to as intraperitoneal hyperthermic chemotherapy (IPHC), is instilled during surgery, via an open or closed abdominal approach. The heated chemolytic agent is infused into the peritoneal cavity, raising the temperature of the tissues within the cavity to 106–108 °Fahrenheit (F). Because various tissue thicknesses are present within the peritoneal cavity, there is a concern that the entire cavity may not be receiving an even exposure to the medication. Extensive surgical debulking is imperative.