Inflammatory Bowel Disease IBD refers to a chronic and relapsing inflammatory disorder of the gastrointestinal tract GIT accompanied by abdominal pain, rectal bleeding and malabsorption. It comprises two (2) major entities, ulcerative colitis UC and Crohn's disease CD.
Serologic panels of multiple antibodies are proposed to aid in differential diagnosis of CD versus UC in stratifying individuals according to disease phenotype and risk of complications.
Examples of serological markers/laboratory tests include:
- Anti-neutrophilic cytoplasmic antibody (ANCA), perinuclear anti-neutrophilic cytoplasmic antibody (pANCA)
- Anti-saccharomyces cerevisiae antibody (ASCA)
- Anti-outer membrane porin C (anti-OmpC) antibody
- Anti-CBir1 flaggellin (anti-CBir1) antibody
- Anti-laminaribioside carbohydrate IgG (ALCA)
- Anti-laminarin (anti-L)
- Anti-chitobioside carbohydrate IgA (ACCA)
- Anti-mannobioside antibodies IgG (AΣMA ) or AMCA)
- Pseudomonas associated sequence I-2 (Anti-I2)
- Antibodies against exocrine pancreas (PAB)
- Antibodies to goblet cells (GAB)