Professional Statements and Societal Positions Guidelines
National Comprehensive Cancer Network – 2021
Esophageal and Esophageal Junction Cancers
The NCCN guidelines (v.4.2021) for esophageal cancer state that radiofrequency ablation has become the preferred treatment while PDT is an alternative strategy for individuals who have Barrett esophagus with HGD. The guidelines also state that PDT can effectively treat esophageal obstruction but "is less commonly performed due to photosensitivity and costs" compared with radiotherapy and brachytherapy.
Hepatobiliary Cancers
The NCCN (v.5.2021) guidelines on hepatobiliary cancers describe PDT as a relatively new therapy for local treatment of unresectable cholangiocarcinoma, stating that the combination of PDT and biliary stenting "was reported to be associated with prolonged overall survival in individuals with unresectable cholangiocarcinoma based on two (2) small randomized clinical trials.
Non-Small-Cell Lung Cancer
The NCCN guidelines (v.6.2021) on non-small-cell lung cancer state that PDT is a treatment option for individuals with locoregional recurrence of non-small-cell lung cancer with an endobronchial obstruction or severe hemoptysis.struction or severe hemoptysis.
