Tebentafusp-tebn (Kimmtrak) (ARCHIVED)

Policy ID: I-248-006

Section: Injections

Effective Date: April 01, 2022

Revised Date: October 24, 2024

Revision Effective Date: December 08, 2024

Last Reviewed: November 19, 2024

Applies To: Commercial Only

**This policy has been Archived effective December 08, 2024. Click the Archive tab above for more information.**

Policy ID: I-248-006

Section: Injections

Effective Date: April 01, 2022

Revised Date: October 24, 2024

Revision Effective Date: December 08, 2024

Last Reviewed: November 19, 2024

Archived Date: December 08, 2024

Applies To: Commercial Only

Description

Tebentafusp-tebn (Kimmtrak ^(R) ) is a bispecific glycoprotein 100 (gp100) peptide-human leukocyte antigen (HLA)-directed CD3 T-cell engager, a type of immunotherapy that simultaneously binds to both T-cell CD3 receptors and gp100 antigens on tumor cells, inducing tumor lysis via an inflammatory response.

Policy Application

All claims submitted for this policy will be processed according to the policy effective date and associated revision effective dates in effect on the date of service.

Criteria

Coverage is subject to the specific terms of the member's benefit plan.

Federal Employee Program members (FEP) should check with their Retail Pharmacy Program to determine if prior approval is required by calling the Retail Pharmacy Program at 1-800-624-5060 (TTY: 1-800-624-5077). FEP members can also obtain the list through the www.fepblue.org website.

Tebentafusp-tebn (Kimmtrak) may be considered medically necessary for individuals 18 years of age or older for the following:

Uveal Melanoma

Treatment of individuals with HLA-A*02:01-positive, unresectable or metastatic uveal melanoma; or

Compendia Sources

Tebentafusp-tebn (Kimmtrak) may be considered medically necessary for treatment of any of the current category 1 or 2A NCCN recommendations.

The use of tebentafusp-tebn (Kimmtrak) not meeting the criteria as indicated in this policy is considered experimental/investigational and therefore non-covered because the safety and/or effectiveness of this service cannot be established by the available published peer-reviewed literature.

Procedure Code

J9274

NOTE: In addition to the above criteria, product specific dosage and/or frequency limits may apply in accordance with the United States Food and Drug Administration (U.S. FDA)-approved product prescribing information, national compendia, Centers for Medicare and Medicaid Services (CMS) and other peer reviewed resources or evidence-based guidelines.

Diagnosis Codes

Covered Diagnosis Codes for J9274

C69.30

C69.31

C69.32

C69.40

C69.41

C69.42

C69.60

C69.61

C69.62

Professional Statements and Societal Positions Guidelines

Not Applicable

ND Committee Review

Internal Medical Policy Committee 3-23-2022 Effective April 01, 2022

Adopted new precertification drug policy

Internal Medical Policy Committee 7-21-2022 Effective July 01, 2022

Added new code, C9095, to the policy

Internal Medical Policy Committee 9-28-2022 Effective October 01, 2022

Added new code, J9274, and
Removed code, C9095, from the policy

Internal Medical Policy Committee 9-12-2023

Annual review , no clinical content change

Internal Medical Policy Committee 9-17-2024 Effective November 01, 2024

Annual review no clinical content change

Internal Medical Policy Committee 11-19-2024 Effective December 08, 2024

Archived policy

Links

References (PDF)

Disclaimer

Current medical policy is to be used in determining a Member's contract benefits on the date that services are rendered. Contract language, including definitions and specific inclusions/exclusions, as well as state and federal law, must be considered in determining eligibility for coverage. Members must consult their applicable benefit plans or contact a Member Services representative for specific coverage information. Likewise, medical policy, which addresses the issue(s) in any specific case, should be considered before utilizing medical opinion in adjudication. Medical technology is constantly evolving, and the Company reserves the right to review and update medical policy periodically.

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